What is APOL1 CKD?
The APOL1 gene helps the body fight certain infections, but some variants (G1 and G2) of this gene are associated with a higher risk of kidney disease. These variants are more common in people of African descent. Carrying one or both of these variants can increase a person’s risk of developing kidney disease, especially if they carry two variants.
While many people with APOL1 variants will never experience kidney disease, those who do may face a more aggressive form that can progress faster than other types of CKD. This is especially concerning in children, as APOL1 CKD can have a lasting impact on their growth, development, and quality of life.
Recognizing APOL1 CKD Symptoms in Children
CKD in children may not show symptoms in the early stages, making it challenging to recognize. Symptoms of more advanced CKD in children may include:
Fatigue and weakness: Reduced kidney function can cause anemia, making children feel more tired than usual.
Swelling: Fluid buildup may lead to swelling, especially in the legs, feet, or face.
Loss of appetite: Kidney issues can impact digestion, causing a child to eat less or complain of nausea.
Slowed growth: CKD can interfere with growth and bone development in children.
High blood pressure: This can develop early in APOL1 CKD, sometimes before any other symptoms appear.
It’s important for caregivers to monitor their child’s health and consult their doctor if these
symptoms arise, especially if there is a family history of kidney disease.
How is APOL1 CKD Diagnosed in Children?
If a child is suspected to have CKD, doctors typically start with blood and urine tests to assess kidney function. To determine if APOL1 gene variants are present, a genetic test may be performed. Knowing whether a child has APOL1 CKD can help caregivers and healthcare providers make informed decisions about treatment and lifestyle adjustments to slow disease progression.
Managing APOL1 CKD in Children
Once a child is diagnosed with APOL1 CKD, a healthcare provider may recommend various strategies, including:
Dietary adjustments: Reducing sodium, protein, and potassium in the diet can help ease the kidneys’ workload.
Medications: Blood pressure medications and other supportive treatments can slow CKD progression and relieve symptoms.
Regular monitoring: Frequent check-ups allow doctors to keep an eye on kidney function and address changes early.
Management is tailored to each child’s specific needs, with an emphasis on promoting growth and overall well-being.
Exploring Clinical Trials as an Option
When it comes to rare and genetically linked conditions like APOL1 CKD, clinical trials can be a valuable option. Clinical trials allow researchers to test new treatments and therapies.
Participating in a clinical trial can benefit children and their families in multiple ways:
Access to specialized care:Â Clinical trials often offer comprehensive support and resources.
Contribution to future treatments: Families who take part in research play a crucial role in advancing science for future generations affected by APOL1 CKD.
The AMPLITUDE Clinical Research Study: A Unique Opportunity for Children with APOL1 CKD
The AMPLITUDE clinical research study is designed to explore new treatments specifically for APOL1 CKD. This study aims to provide insights into better ways of managing and potentially treating this genetic form of CKD. Caregivers who choose to enroll their child in the AMPLITUDE study will receive study-related medical assessments, monitoring, and treatments.
How Caregivers Can Get Involved
If you are caring for a child with APOL1 CKD, consider the AMPLITUDE clinical research study. Talk to your child’s healthcare provider about the study, or click here to learn more.
Help contribute to the advancement of APOL1 CKD care by considering participation in the AMPLITUDE study today.
References
American Kidney Fund. APOL-1 Mediated Kidney Disease
American Association of Kidney Patients. APOL 1 Gene
National Kidney Foundation. APOL1-Mediated Kidney Disease (AMKD)
Neph Cure for Rare Kidney Disease. APOL1 Kidney DIsease
